Pdgfra-creert2

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August undefined, 2024

Splet23. sep. 2024 · As PDGFRα is expressed in a majority of murine adult cardiac fibroblasts (Ivey et al., 2024; Pinto et al., 2016), we induced diphtheria toxin A (DTA) expression using a Pdgfra CreERT2/+ mouse line to deplete resident fibroblasts (Chung et al., 2024). The DTA expression following tamoxifen treatment led to fibroblast loss within several days. Splet22. mar. 2024 · Postnatal deletion of the Igf1r gene impairs alveolarization. Constitutive deletion of the mouse Igf1r gene caused respiratory failure following birth ().Since the deletion of Igf1r with an epithelial-specific Nkx2-1-Cre did not alter lung morphogenesis (), we tested whether its conditional deletion in lung fibroblasts influenced postnatal lung …

OPC perivascular clusters following demyelination represent a …

Splet029684 - Pdgfr-β-CreER [T2] Strain Details. Technical Information Scientists. Overview. SpletN1 - Funding Information: We thank D. Bergles (Johns Hopkins School of Medicine) for providing NG2DsRed and Pdgfra-creERT2 mice, M. Turmaine for assistance with electron microscopy, and L.-J. Chew for comments on the manuscript. byron\u0027s southampton

Pdgfra-Cre

Splet01. apr. 2024 · TL;DR: Results demonstrate that autophagy is an important mechanism related to Klfs in smooth muscle cells during AAA formation, and Chromatin immunoprecipitation assays demonstrated that Klf4, Klf2, and Zfp148 separately bind autophagic genes in smooth Muscle cells following elastase treatment. Abstract: … SpletTo investigate the role of macroautophagy/autophagy in AT fibrogenesis, we used Pdgfra-CreErt2 transgenic mice to create conditional deletion of Atg7 alleles in AT progenitor cells (atg7 cKO) and examined sex-dependent, depot-specific AT remodeling in high-fat diet (HFD)-fed mice. Splet04. sep. 2024 · This differs from the results from a recent lineage tracing study using a Pdgfra-CreERT2 BAC transgenic line, which showed that lineaged cells gave rise to more lipofibroblasts than myofibroblasts at the same stage (P7) (Ntokou et al., 2015). The difference of the results may be due to differences in the cell populations that are … clothing optional gran canaria

JDB Free Full-Text Epicardial Origin of Resident Mesenchymal …

Tg(Pdgfra-cre/ERT2)1Wdr Transgene Detail MGI Mouse …

Splet06. apr. 2024 · (A) Whole-mount images of SI from Pdgfra CreERT2;R26R mT/mG mice, where Cre-expressing cells convert ubiquitous tdTom fluorescence (red) to eGFP signal (green), counterstained for F-actin (phalloidin, white). 30 μm z stack overlay. The dashed box is enlarged to the right and the crypt in that image is marked with a dashed white line. SpletMutation details: A mouse PAC clone (RPCI21-546M3) containing the Pdgfra gene was modified by the insertion of a tamoxifen-inducible cre recombinase gene into exon 2 … clothing optional hotel floridaSpletThe data suggest that Pdgfrα-CreERT2 transgenic mice can be used to achieve robust recombination in OPCs, while having a minimal effect on most PDGFRα+ cell populations outside of the CNS. In the central nervous system (CNS) platelet derived growth factor receptor alpha (PDGFRα) is expressed exclusively by oligodendrocyte progenitor cells … byron\\u0027s smokehouse hand pulled pork bar-b-q

"Splet06. apr. 2024 · (A) Whole-mount images of SI from Pdgfra CreERT2;R26R mT/mG mice, where Cre-expressing cells convert ubiquitous tdTom fluorescence (red) to eGFP signal (green), counterstained for F-actin (phalloidin, white). 30 μm z stack overlay. The dashed box is enlarged to the right and the crypt in that image is marked with a dashed white line. " - Pdgfra-creert2

Pdgfra-creert2

PDGFRβ-P2A-CreERT2 mice: a genetic tool to target pericytes in

Splet19. mar. 2024 · Pdgfra-CreERT2 mice were a kind gift from Bill Richardson (University College London, London, UK). Fra-2 Tg mice were kindly provided by Erwin Wagner (Research Institute of Molecular Pathology-IMP, Vienna, Austria). We appreciate excellent technical assistance by Thomas Fuchs, Visnja Bubalo, Alexandra Treitler, and Tatjana … Splet关于我们杰克森实验室（jax）是一家独立的非盈利性生物医学研究机构，拥有超过3,000名员工。其总部位于缅因州巴港，并在此设立了一家由美国国家癌症中心指定的癌症研究中心。

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Splet08. okt. 2008 · About 4% of the cells in the adult rodent brain are PDGFRA+ NG2+ glia, derived from the oligodendrocyte lineage. Rivers and colleagues constructed a transgenic mouse to fate map the PDGFRA+ glia. Splet27. jul. 2024 · As a proof of principle that the PDGFRβ - P2A - CreER T2 mouse line is an efficient tool to drive genetic modifications in perivascular cells, we used it to specifically …

Splet15. mar. 2024 · Fosl2tg; Pdgfra-CreERT2; tdTomatoﬂox, Fosl2tg; Acta2-CreERT2; tdTomatoﬂox, and littermate controls were eutha-nized, and lungs harvested at 20 wk of … Splet01. jul. 2024 · We conclude that the PDGFRβ-P2A-CreERT2 line is a powerful new tool to target pericytes and will aid the field in gaining a deeper understanding of the role of …

Splet032770 B6.129S- Pdgfra tm1.1(cre/ERT2)Blh /J Pdgfrα-CreER T2 mice have a cre/ERT2 fusion gene inserted into the start codon of the platelet derived growth factor receptor, … SpletA transgenic mouse line, Pdgfra-CreERT2, allowed temporally-controlled, permanent activation of YFP expression in PDGFRa-expressing OLPs and their differentiated progeny in the Rosa26-YFP reporter background. In vivo BrdU labelling and fate mapping of YFP-positive cells revealed that, in the corpus callosum, approximately half of the OLPs were ...

Splet04. sep. 2024 · In the normal lungs during alveologenesis, using a BAC transgenic Pdgfra-creERT2 line in lineage tracing, it was reported that Pdgfra+ cells give rise to both …

Splet14. sep. 2016 · In the central nervous system (CNS) platelet derived growth factor receptor alpha (PDGFRα) is expressed exclusively by oligodendrocyte progenitor cells (OPCs), … byron\u0027s south endSpletPericytes are essential mural cells distinguished by their association with small caliber blood vessels and the presence of a basement membrane shared with endothelial cells. … clothing optional hotel key westSpletSham and overloaded mesenchymal progenitors from Control (Pdgfra-CreERT2) or cdKO (Pdgfra-CreERT2::Yap1 flox/flox ::Taz flox/flox) were used for RNA-seq analysis. Contributor(s) Kaneshige A, Kaji T, Yasuyuki O, Fukada S: Citation(s) 34856120: Submission date: Dec 08, 2024: Last update date: Feb 18, 2024: clothing optional hotels in arizonaSpletBy using this site, you agree to our Terms and Conditions Got it! byron\\u0027s south end charlotteSplet21. jul. 2024 · 如果不知道来源，可以尝试从引物的序列入手。. 先通过blast来查找引物所配对的序列来源，然后逆推转基因的设计。. Pdgfra-creER 转基因小鼠是由Pdgf receptor a … byron\\u0027s south endSpletFig1. Cre-mediated recombination in the large and small intestine of Pdgfra Cre/+; Rosa26 tdTomato/+ mouse.. Fig2. Cre-mediated recombination in the retina of Pdgfra Cre/+; Rosa26 tdTomato/+ mouse.. Fig3. Detection of tdTomato(red) in various tissues of Pdgfra Cre/+; Rosa26 tdTomato/+ mice. Tdtomato can be detected in the brain, retina, pituitary gland, … clothing optional hotels gran canariaSpletIn this line of Pdgfra-CreERT2 mice, both Pdgfra mRNA (c) and Cre mRNA (d) were found in cells scattered through the brain, as expected for PDGFRA-positive OLPs (c and d are … byron\u0027s south end charlotte