Tmem63a是什么
Transmembrane protein 63A is a protein that in humans is encoded by the TMEM63A gene. The mature human protein is approximately 92.1 kilodaltons (kDa), with a relatively high conservation of mass in orthologs. The protein contains eleven transmembrane domains and is inserted into the membrane of … See more Overview TMEM63A is located on the negative DNA strand of chromosome 1 at location 1q42.12, spanning base pairs 226,033,237 to 226,070,069. Aliases include KIAA0489 and KIAA0792. The … See more Properties and characteristics The mature form of the human TMEM63A protein has 807 amino acid residues with an isoelectric point of 6.925. This is fairly conserved across … See more • Gregory SG, Barlow KF, McLay KE, et al. (2006). "The DNA sequence and biological annotation of human chromosome 1". Nature. 441 (7091): … See more Paralogs TMEM63A has two paralogs: TMEM63B, which is located at 6p21.1, and TMEM63C, which is located at C14orf171. Alignment between them shows that TMEM63C is more closely related to TMEM63B than TMEM63A. A BLAST … See more WebAnti-TMEM63A antibody produced in rabbit Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody; Synonyms: KIAA0792; find Sigma-Aldrich-HPA066504 MSDS, related peer-reviewed papers, technical documents, similar …
Tmem63a是什么
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WebImmunocytochemistry/ Immunofluorescence - Anti-TMEM63A antibody (ab221878) PFA-fixed, Triton X-100 permeabilized RT4 (Human bladder transitional-cell carcinoma cell line) cells stained for TMEM63A (green) using ab221878 at 4 ug/ml in ICC/IF. Protocols. Immunocytochemistry & immunofluorescence protocols. WebStrikingly, TMEM63A in turn stabilizes oncoprotein DERL1 through preventing TOLLIP-mediated autophagic degradation. Notably, pharmacological inhibition of VCP by CB-5083 or knockdown of DERL1 partially abolishes the oncogenic effects of TMEM63A on TNBC progression both in vitro and in vivo. Collectively, these findings uncover a previously ...
WebJul 31, 2024 · TMEM63A, TYR559HIS. RCV002271995. In a 15-month-old girl with hypomyelinating leukodystrophy-19 (HLD19; 618688 ), Tonduti et al. (2024) identified a de … WebAug 3, 2024 · Here, we report for the first time that TMEM63A (transmembrane protein 63A), a poorly characterized TMEM protein with unknown functions in human cancer, functions as a novel oncogene to promote ...
WebFeb 1, 2024 · We found a de novo variant in TMEM63A (NM_014698.3:c.1658G>T, p.(Gly553Val)), which was validated by Sanger sequencing (Fig. 2 A). This variant … WebCatalog #. AM16708. Standard 5 nmol. Purification: HPLC In-Vivo Ready Standard. Size: 5 nmol 20 nmol 20 nmol 20 nmol 20 nmol 40 nmol 40 nmol 100 nmol 250 nmol 250 nmol 1 …
WebImmunofluorescence showed that TMEM63A was localized to the cell membrane. Flow cytometric analysis revealed that TMEM63A was expressed in the majority of goat PBMCs. After using RNA interference to knockdown expression of TMEM63A, the PBMC proliferation and migration were significantly increased, while the influence of rHco-gal-m on
WebTmem63a. Name. transmembrane protein 63a. Synonyms. MGC:11687, MGC:25803. Feature Type. protein coding gene. IDs. MGI:2384789. cultural setting of a piece of stringWebApr 9, 2015 · Our results show that TMEM63A is a binding partner of Hco-gal-m/f, and involved in the immune responses of host PBMCs induced by Hco-gal-m for the first time. Hco-gal-m and -f were two isoforms of galectin cloned from male and female Haemonchus contortus, respectively, and it was demonstrated that recombinant Hco-gal-m and -f could … cultural shifts during the great depressionWebNov 8, 2016 · Spinal cord involvement and paroxysmal events in "Infantile Onset Transient Hypomyelination" due to TMEM63A mutation. The N- and C-terminal carbohydrate recognition domains of Haemonchus contortus galectin bind to distinct receptors of goat PBMC and contribute differently to its immunomodulatory functions in host-parasite … east lothian witch trialsWebNov 1, 2024 · Mechanically activated (MA) ion channels convert physical forces into electrical signals, and are essential for eukaryotic physiology. Despite their importance, … east lothian women\u0027s aidWebJul 12, 2024 · Introduction. Amputation per se is a severe physical and psychological traumatic event with a high incidence worldwide. In addition, up to 70%–80% of patients with amputation experience severe chronic post-amputation pain (CPAP), which can be devastating [1, 2].CPAP is a long-lasting and severe pain after amputation surgery … cultural shock in usWebMar 30, 2024 · Monoallelic mutations on TMEM63A have been recently reported as cause of a previously unrecognized disorder named “infantile-onset transient hypomyelination”. Clinical and neuroradiological ... east lothian worksWebApr 9, 2015 · The localization of transmembrane protein 63A (TMEM63A) in peripheral blood mononuclear cells (PBMCs) was detected by immunofluorescence. The distribution of TMEM63A in T cells, B cells and monocytes in PBMCs was detected by flow cytometry. The immunomodulatory effects of Hco-gal-m and TMEM63A on cell proliferation, migration, … east lothian works service plan